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In the STEP 1 extension, people who stopped semaglutide regained 11.6 percentage points of body weight over 52 weeks, ending with an average net loss of 5.6% from baseline while lifestyle support continued (STEP 1 extension data)

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The study also found that after semaglutide intervention, the food intake of obese mice decreased significantly, achieved by regulating appetite-related factors in the hypothalamus, indicating that semaglutide could penetrate the blood-brain barrier to reach the hypothalamus, brainstem, and arcuate nucleus through peripheral administration ( + neurons in the arcuate nucleus co-express GLP-1R and leptin receptors, and chemogenetic activation of POMC Glp1r+ neurons leads to reduced food intake in male mice ( In addition to regulating appetite, the semaglutide also affects insulin secretion, blood glucose homeostasis, energy expenditure, and lipid metabolism processes, as well as serum metabolism

2018 Apr 3;27(4):740-756

Talk to your doctor before taking GLP-1 medications if you have any of the following conditions: A personal or family history of medullary thyroid cancer or acute pancreatitis Type 1 diabetes mellitus Pregnant, planning to become pregnant in the next 3 months, or nursing Delivered a baby within the past 6 months Ongoing heavy alcohol use Active eating disorder, anorexia, or purging

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