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Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy

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These findings were further corroborated within the Lifelines Cohort, where results showed sex- and duration-specific DNA methylation changes in women exposed to intermediate-term NSW (10-16 years), enriched in pathways related to circadian regulation and cellular senescence

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The rise of the ATP:ADP ratio in the cytoplasm closes the plasmalemmal ATP-sensitive potassium channel (K ATP ), resulting in depolarisation of the plasma membrane, which triggers the opening of the voltage-gated Ca 2+ channel [5]

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