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Broad Gene-Expression Signal (experimental): Reported studies show changes in gene sets tied to ECM remodeling, antioxidant defenses, inflammatory signaling, and nervous-system pathways

Cost Impacts to Health Plans Rising Pharmacy Costs: Health plans could face a 20%35% increase in overall pharmacy spending for members with diabetes or obesity

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However, because Retatrutide remains investigational, researchers continue to evaluate how frequently these effects occur and how they can be managed effectively

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Mental health considerations have emerged as a key concern