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Proper technique reduces but does not eliminate this risk

Chronic sleep deprivation or poor sleep quality impairs these restorative processes, potentially reducing glutathione synthesis capacity and increasing oxidative stress through various mechanisms including increased inflammatory signaling, impaired glucose metabolism, disrupted circadian rhythms affecting antioxidant enzyme expression, and increased psychological stress responses

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The average patient age was 75 years (range: 23 to 102 years)

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