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Semaglutide's cardiovascular benefit in the SELECT trial (reduction in major adverse cardiovascular events) was demonstrated at 2.4 mg, not at microdoses (Lincoff et al., NEJM 2023)

Similar fragility applies to tirzepatide , which shares structural complexity as a fellow GLP-1 receptor agonist

Fasting glucose levels consistently below 70 mg/dL, or symptoms like shakiness, confusion, and sweating, should prompt a blood glucose check and medication adjustment discussion

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