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Remdesivir is a nucleoside analog that inhibits the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, which results in impaired viral replication [62]

Thus, all three of the main UA transporters may contribute to the brain concentrations of UA through their action at the blood-brain barrier, although ABCG2 is thought to have the greatest effect, probably acting to remove UA from brain to blood 45

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