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Persistent vomiting or diarrhoea can lead to dehydration, which in some cases may affect kidney function

Transcriptome and metabolome analysis of the responses of saline and alkaline resistance of different Helianthus annuus germplasms to melatonin

Zhang Z, Guo M, Shen M, Kong D, Zhang F, Shao J, et al

This reduced response is driven by insulin resistance, diabetic medications (some of which promote weight gain), and metabolic dysfunction that blunts the full effect of GLP-1 therapy