The findings of the rapid and long-lasting antidepressant effects of LAC (which increases the expression of mGlu2, inhibitor of spontaneous glutamate release) supports the idea that targeting the glutamate system can lead to rapid antidepressant effects in agreement with the prior discovery of the antidepressant action of ketamine [48,49,50]
Mechanism of action of methyldopa at the presynaptic adrenergic neuron
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J.SinclairD.KhoshdelA.LuJ.HuangX.et al (2011)
While preclinical models have yielded valuable insights into microglial heterogeneity, many markers defined in rodent systems [e.g., arginase 1 (Arg1) or rodent-specific chitinase-like protein (Ym1)] have limited expression or different regulation in human microglia
Someone carrying high-risk variants in these pathways may experience faster appetite return and stronger cravings once medication ends compared to individuals with protective genetic profiles
