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Treatment Implications GLP-1 receptor agonists are effective in reducing cardiovascular events and improving metabolic parameters, but (particularly long-term) patient benefit appears greater with surgical intervention

Combination therapy remains largely experimental with limited published safety data

A frozen pen is no longer effective and should be discarded immediately

Most patients see the earliest changes in the first few weeks, with fuller results building over two to three months of steady use

111 Infliximab (IFX) was the first TNFi for RA treatment and consists of a recombinant chimeric monoclonal antibody composed of a human antibody backbone with a mouse idiotype

(5) Slide scanning : The Olympus VS200 Research Slide Scanner was used to acquire datasets for stereology analysis