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One compound that has garnered significant clinical interest is Acetyl-L-Carnitine (ALCAR)

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doi: 10.1093/brain/awg146 113 Schneider-HohendorfTGorlichDSavolaPKelkkaTMustjokiSGrossCCet al

Cut your food intake in half, and you lose 250 to 350 mL of daily water, roughly the equivalent of a large glass