To meet the diagnostic criteria for dEDS, a person must meet: Major criterion 1 AND major criterion 2 AND at least one other major criterion OR Major criterion 1 AND major criterion 2 AND at least three minor criteria Major Criteria Extreme skin fragility with congenital or postnatal skin tears Characteristic craniofacial features, which are evident at birth or early infancy or evolve later in childhood Redundant, almost lax skin, with excessive skin folds at the wrists and ankles Increased palmar wrinkling Severe bruisability with a risk of subcutaneous hematomas and hemorrhage Umbilical hernia Postnatal growth retardation Short limbs, hands, and feet Perinatal complications due to connective tissue fragility Minor Criteria Soft and doughy skin texture Skin hyperextensibility Atrophic scars Generalized joint hypermobility Complications of visceral fragility (e.g., bladder rupture, diaphragmatic rupture, rectal prolapse) Delayed motor development Osteopenia Hirsutism Tooth abnormalities Refractive errors (myopia, astigmatism) Strabismus Kyphoscoliotic EDS (kEDS) If a person meets the diagnostic criteria for kEDS, genetic testing should be done to confirm the diagnosis
Plant Extracts: Mild headache or digestive discomfort has been reported in some cases
There are safer and more scientifically backed methods to achieve and maintain a healthy weight
The subcutaneous injection guide covers administration technique
Its likely that GLP-1 users snacked more between meals prior to starting a GLP-1, but the medication could also be contributing to reducing appetite for large meals in lieu of smaller and more frequent snacking throughout the day
However, it arrived with no instructions on how to mix and use the drug, and testing by a team from the University of Oxford revealed the substance was not Ozempic
