Coverage for these drugs is considerably broader when diabetes is the documented indication
If someone is so nauseated by their weekly dose that they cannot eat properly for three days, they are not getting adequate nutrition and may be losing muscle rather than fat
JAMA (2019) 321:1457
Rather than implying clinically relevant fat malabsorption, these shifts are more plausibly interpreted as alterations in bile acid signaling and metabolic handling of nutrients that may complement the appetite-suppressive and insulin-sensitizing actions of GLP-1 RAs (86, 87)
It can contribute to heart and kidney injury
Liu H, Wang Y, Zhang W, Sun W, Ji X, Zhang S, Qiao K (2022) Lentinan extends lifespan and increases oxidative stress resistance through DAF-16 and SKN-1 pathways in Caenorhabditis elegans