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Metabolomic analyses of reactive astrocytes in mouse models have revealed that late-stage AD is associated with synaptic dysfunction and neurotransmitter imbalances, primarily due to impaired glutamine synthesis 71
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However, the increase of glutathione (GSH+GSSG and separate GSH and GSSG forms) during HR was more dynamic and stable
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Nature 546 , 248253 (2017)
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