Samples are from rats in main Fig
The side effect profiles of these two compounds are dramatically different, and for some people, that difference tips the scale
However, those taking diuretics, individuals with chronic kidney disease, or patients with cardiac conditions should have potassium levels monitored as advised by their healthcare professional
[5] In any research context it should still be framed research-use-only
Seek medical help right away if you notice: severe or persistent abdominal pain and/or constipation, repeated vomiting, inability to keep fluids down, or fainting signs of an allergic reaction, such as swelling, hives, or trouble breathing (seek emergency care) any new, concerning, or sudden symptom after starting the medication or increasing the dose that doesnt improve Key Takeaways Semaglutide and tirzepatide are effective and safe weight loss medications that are designed to be paired with a healthy diet and exercise
Medically reviewed by Alan Lucks | MD , Alan Lucks MDPC Private Practice - New York on October 23rd, 2025
