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This is critical because droplet size determines where in the nasal cavity the drug deposits: droplets in the appropriate size range (typically 30200 m for nasal sprays) deposit in the nasal turbinates, where absorption occurs, while excessively small droplets may penetrate to the lower respiratory tract, and excessively large droplets may not clear the nasal vestibule
In a typical 70 mg vial reconstituted with 3 mL of bacteriostatic water, that translates to 10 units (0.10 mL) on an insulin syringe
Reported side effects are generally mild and may include nausea, dizziness, headache, or injection site irritation
To further confirm this potential shift in the conformational equilibrium, we collected a second cryo-EM dataset for Cagri-CTR ( N = 2) from a separate protein purification
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References (APA style) Blau, H
