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C) - ascorbate's (from ascorbic acid) potent antioxidant capability is already proven especially with its scavenging activity and high rate of reaction with free radicals (9,10,11)

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Several studies have identified potential biomarkers predictive of CB-839 sensitivity, including the intracellular glutamate/glutamine ratio, expression levels of the GLS isoform GAC, and GLS enzymatic activity (90, 93, 248, 249)

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