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10.1016/j.omtm.2017.04.003 309

Proton-pump inhibitors (e.g., omeprazole, esomeprazole, and lansoprazole), used to treat Zollinger-Ellison syndrome and gastroesophageal reflux disease (GERD), markedly decrease stomach acid secretion required for the release of vitamin B 12 from food but not from supplements

However, genetic predisposition does not predict exact supplementation response

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N-acetyl-cysteine The beneficial effects of N-acetyl-cysteine (NAC) treatment are attributed to its antioxidant and anti-inflammatory properties (Ozaydin 2008)