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55 Together, the combined actions of various disorders in the proximal signaling components leads to impaired glucose metabolism and IR, and a major challenge remains for understanding IR mechanisms regarding how to distinguish the causes from insulin effects or primary defects from their consequences

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If nausea persists at the starting dose, consult your prescriber about alternative approaches or dose adjustments

doi: 10.1016/s0928-4257(99)00119-9