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Weight loss should be consistent and exceed your semaglutide trajectory

Potential mechanisms linking both are impaired dopamine signaling and inflammation (also see below), which both alter reward sensitivity and have been shown to be altered in DM2 and anhedonia [120]

Self-Reported Side Effects of Semaglutide and Tirzepatide in Online Communities

This slow approach can give your body time to adjust and might reduce the severity of side effects like nausea or vomiting

Do not strain

When paired with diet and exercise, semaglutide can lead to significant weight loss and reduce the risk of conditions like cancer, diabetes, and heart disease in overweight or obese individuals