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This indicated that HO-1 exhibits excellent benefits in ferroptosis of DN since it is an important downstream target affected by HGBM1
Mcbean et al., 2015
A detailed analysis of the regulatory pathways is provided, encompassing hormone regulation, adenosine monophosphate-activated protein kinase and mechanistic target of rapamycin signaling, and the impact of the sirtuin (SIRT) protein family, emphasizing the roles of metabolic products or non-metabolic enzymatic functions in energy metabolism
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