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While B12 is important for blood cells, nerves, and DNA, excessive intake can lead to problems

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We detected the formation of acrylamide adducts with thiol groups from both metabolites and protein residues, leading to a quasi-complete depletion of glutathione and to the inactivation of different components of the thioredoxin system

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Niacinamide and alpha arbutin are generally the gentlest options