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Its superoxide-mediated oxidation generates the fluorescent product 2-hydroxyethidium (2-E + OH) ( excitation = 500 nm, emission = 600 nm), while other ROS or reactive nitrogen species (RNS) do not form the same fluorescent product when reacting with DHE (Zhao et al., 2003

This pattern reflects the underlying biology rather than treatment failure

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It plays a key role in the inflammatory response and can be activated by various stimuli to regulate the expression of numerous inflammation-related genes