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The entire active mTORC1 assembly showed a large membrane-covering footprint (Fig
patients should remain on 3 mg 1 time a week dose for at least 4 weeks before increasing the dose to 4.5 mg once a week
Lyophilization (freeze-drying): Preserves integrity and extends shelf life
These are usually mild and diminish with continued use
Reconstituted : May be damaged Visual inspection for crystals If looks clear, might still work but potency uncertain Consider reconstituting fresh vial Left in hot car Powder : Hours: Probably fine Days: Likely degraded Visual inspection won't help Effectiveness test only way to know Reconstituted : Likely degraded significantly Discard and reconstitute fresh Dropped and shattered Safety first : Clean up carefully, glass hazard
Five enzymes of the Arg/N-degron pathway form a targeting complex: the concept of superchanneling
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