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The entry of these substances triggers a local inflammatory response within the brain tissue itself, characterized by microglial activation and the production of additional pro-inflammatory cytokines (Varatharaj and Galea, 2017

More specifically, they noted that at least one subject's Central corneal endothelial cells (CEC) density measurement was not completed before enrollment, which was one of the enrollment criteria, and another enrolled subject had Intraocular pressure (IOP) that was outside the criteria

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