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While direct evidence in humans is limited (for obvious ethical reasons), the mechanism of action is concerning enough to make this one of the most serious GHK-Cu contraindications

Its selectivity is its signature trait unlike older GHRPs (GHRP-6, GHRP-2), it produces GH release with minimal cortisol or prolactin effects, making it a cleaner research tool

Altogether, these findings indicate that exogenous administration of GH induces an orexigenic response via activation of AgRP neurons

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Spectroscopic and chemical studies of the interaction between nerve growth factor (NGF) and the extracellular domain of the low affinity NGF receptor