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GLP-1 receptor agonists are not recommended in patients with a family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2A or 2B, due to an association between GLP-1 receptor agonists and benign and malignant thyroid C cell tumors in rodents [49]

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Aged mice (22 months, equivalent to roughly 65 to 70 human years) treated with MOTS-c three times per week doubled their running capacity on treadmill tests

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For BALF and cell culture supernatants, 100 l sample were used and the results expressed as a concentration in ng/ml