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The degeneration of retinal ganglion cells and axon loss is characteristic of glaucomatous optic neuropathy and reduction in mechanisms potentiating this process would ultimately reduce glaucoma progression and severityas confirmed by our results, the researchers noted in their paper, adding that reductions in inflammatory oxidative stressors such as C1q, TNF-a and IL1a have also been documented. In summary, these findings confirm the significant protective effects of GLP-1RAs on the incidence and progression of primary open-angle glaucoma, though the authors caution that further research is warranted to explore the mechanisms by which GLP-1RAs confer these protective effects, particularly in non-diabetic populations. 1
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