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Lower purity products contain impurities that may affect both safety and efficacy

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23: 414424, doi: Di Marzio L, Moretti S, DAlo S, Zazzeroni F, Marcellini S, Smacchia C, Alesse E, Cifone MG, De Simone C

In the SUSTAIN clinical trial program evaluating semaglutide for type 2 diabetes, gastrointestinal adverse events were reported by approximately 30-50% of participants, with the incidence varying by dose