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doi:10.1074/jbc.M706204200 Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ

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It reveals that altered glutathione and AA homeostasis induced by Trkb deletion in iSPNs is directly linked to early dopaminergic dysfunction and disrupted energy metabolism followed by age-dependent motor impairment and strongly supports the relevance of our model to elucidate the mechanisms underlying the vulnerability of iSPNs in neurodegenerative conditions

A., Vincent, C