Biomedicine & Pharmacotherapy, 177 , Article 117093
In general, excess ROS causes the production of a few enzymes, such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, xanthine oxidase (XO), lipoxygenase (LO), cytochrome P450 (CYP450), myeloperoxidase (MPO), iron (Fe), and copper (Cu) proteins
This more aggressive approach requires careful monitoring and may suit men who tolerated the initial doses without difficulty
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The typical starting dose is low, often around 2.5 mg once weekly, to reduce side effects