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Clinical reports document taste alterations and xerostomia in patients using semaglutide 47 , with studies implicating GLP-1R expression in mammalian taste buds and their role in modulating gustatory sensitivity 48
While the studys design as an open-label trial warrants consideration when interpreting results, the trial supports the superiority of tirzepatides dual-action mechanism targeting both GIP and GLP-1 receptors, compared to semaglutides single GLP-1 receptor targeting approach
Yang, Y
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