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Thus, the etiology of primary cerebral folate deficiency includes the presence of autoantibodies against the folate receptor (FR1) and mutations in the FOLR1 gene, which encodes the FR1 protein [101]

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their association with SGLT-2 inhibitors requires further confirmation through large, randomized trials ( SGLT2 inhibitors should be discontinued in specific clinical scenarios to mitigate potential adverse events

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Spiller HA, Krenzelok EP, Klein-Schwartz W, Winter ML, Weber JA, Sollee DR, Bangh SA, Griffith JR: Multicenter case series of valproic acid ingestion: serum concentrations and toxicity