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Proteins in the samples were precipitated by boiling or treating with 10 % cold perchloric acid and then centrifuging at 4 C and 12,000 rpm for 10 min

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doi: 10.1038/s41522-025-00663-4 110 OhH

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In pharmacokinetic studies, patients with moderate and severe hepatic impairment had higher systemic exposure to the drug than healthy subjects