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The combination treatment effectively delayed tumor growth and blocked EGFR by decreasing the phosphorylation of STAT3, p38 MAPK, ERK1/2, and BAD proteins, while the IC 50 value of CHE was between HCC827 (IC 50= 5.0 0.48 M), SK-MES-1 (IC 50= 6.35 1.26 M), and A459 (IC 50= 7.78 0.56 M) ( These studies provide a new perspective on the anticancer therapeutic strategy of CHE in combination therapy

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Facts 6 , 203210 (2013)

The Downside: Managing Side Effects Of course, no medication is without its potential downsides