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On the one hand, in mitochondria, Glu is then transformed into -Ketoglutaric acid (-KG) via glutamate dehydrogenase 1 (GLUD1), glutamic oxaloacetic transaminase 2 (GOT2) and glutamate pyruvate transaminase 2 (GPT2) (10)

NNMT (Nicotinamide N-Methyltransferase) Inhibition Potently and selectively binds to the nicotinamide binding site of NNMT, blocking the methylation of nicotinamide using SAM 4

A reduction in NAD + synthesis is one of the main causes of NAD depletion in aging

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Biol Chem, 2003