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GLP-1 receptors in your brain that were suppressing appetite become less activated, leading to increased hunger hormones like ghrelin

Nature 460 , 11591163 (2009)

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However, clinical studies have shown promising results: Average Weight Loss: Clinical trials indicate that people using GLP-1 for weight loss typically lose around 15-20% of their body weight over a period of 68 weeks (approximately 1 year and 3 months), when combined with a reduced-calorie diet and increased physical activity