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Conceptually, its practical significance has been ascribed to its particular role in the Selyes stress response [3,7,8], as well as to its resolving of activities of the braingut and gutbrain axes [7,12]

DOI: 10.1016/j.annemergmed.2010.03.008

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This explains why topical applications achieve far lower tissue concentrations than injection

doi: 10.1155/2016/3094642 43 RakipovskiGRolinBNhrJKleweIFrederiksenKSAugustinRet al

The study found that patients without diabetes lost more weight than patients with diabetes