While combination therapy was not statistically superior to high-dose monotherapy, it was effective, safe and may offer a reasonable alternative for patients not responding to standard doses
doi: 10.1089/thy.2020.0299 90 FaamBGhadiriAAGhaffariMATotonchiMKhorsandiL
In the late stages of PD, the key molecular pathogenic mechanisms include the misfolding and aggregation of -synuclein, mitochondrial dysfunction, impaired protein clearance (related to inefficient ubiquitin-proteasome and autophagy-lysosomal systems), neuroinflammation and oxidative stress (57)
This may be a surprise, but the idea of using GLP-1 drugs for Alzheimers isnt new its been discussed in scientific literature for over 20 years
Phosphorylated form of SQSTM1 physically interacted with KEAP1, an adaptor of the ubiquitin ligase complex for Nrf2, with high affinity (Ueno and Komatsu, 2017)
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