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For patients struggling to hold onto a thought or find the right word, supporting acetylcholine synthesis is a critical therapeutic target
In most studies, a decapeptide (EHWSYGLRPG), which is identical to the native GnRH sequence has been used
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To explore whether cystatin C and -amyloid also co-localize in brain amyloid plaques, researchers analyzed transgenic mice carrying the Swedish APP (SweAPP) mutation, leading to elevated A production and early plaque deposition (Steinhoff et al., 2001