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Figure 5 In addition, ATP serves as a neurotransmitter, co-transmitter, and neuromodulator, undertaking an important role in pain processing, and ATP P1 receptors (A1, A2A, A2B, and A3) are found ubiquitously expressed in the nervous system (Franco et al., 2021)

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394 Lesinurad is metabolized and eliminated predominantly by the liver (75%) and to a lesser extent by the kidneys (25%), with a half-life of approximately 9 to 10 h

Song KKH, Han C, Zhang J, Dash S, Lim K, Wu T