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Protection by cyclosporin A of Ischemia/reperfusion-induced damage in isolated rat hearts

In the context of cerebral ischemia, astrocytes are especially important in regulation and maintenance of glutamate during acute injury, which causes excitotoxicity and perturbates calcium influx resulting in cell death ( Per2, Clock , and NPAS2 display significant reductions in glutamate uptake, mRNA expression of Glast, an astrocyte-specific glutamate transporter, and protein expression (Sofroniew, 2015)

If malignant melanoma is found, it is reasonable to stop the TNF inhibitor

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Circulation research, 110(8), 1097-1108

CCL2 is expressed in tumors and affects endothelial permeability and metastasis through interacting with CCR2 expressed on tumor endothelial cells [208]