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Once absorbed, it stimulates fibroblast activity, increases collagen production, and activates antioxidant enzymes

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Cocaine binds with high affinity to the norepinephrine transporter (NET) on the presynaptic nerve terminal (Kd 0.3 M), acting as a transmembrane physical plug that inhibits reuptake of norepinephrine

Effects and potential mechanism of herbs on UC are summarized in Table 2

Seek emergency care or same-day evaluation if any of the following occur: Sudden or severe difficulty breathing Rapid onset, inability to swallow saliva or liquids Signs of severe infection (high fever, neck swelling with redness and pain) Large, rapidly growing neck mass When symptoms are less acute but persistent or worsening over weeks, schedule a timely evaluation with a clinician who can arrange appropriate imaging or referral to an otolaryngologist (ENT) or gastroenterologist

To advance therapeutic translation, future research should prioritize: (i) Gender-stratified validation of clinical biomarkers for early detection