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The mammalian enzymes occur in seven classes 9 of which members of the pi, mu, and alpha classes are major contributors to biotransformation of xenobiotics 10

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Animal studies found no deaths even at doses 1,000 times higher than typical therapeutic use (Sikiric et al., 2014)

Analogously, activation of the KDEL receptor (KDELR) by cargo from the endoplasmic reticulum (ER) was shown to trigger signal cascades via Gs and Gq/11, with KDELR acting as a non-canonical GPCR at the Golgi 4

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This is a critically important distinction that cannot be overlooked