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282 Similarly, lactylation of malate dehydrogenase 2 (MDH2), a key enzyme of the TCA cycle, induces ferroptosis of cardiomyocytes by inhibiting the TCA cycle and impairing mitochondrial function, thereby resulting in myocardial ischemiareperfusion injury (MIRI)

In this context, various flavones and flavonols containing a catechol moiety in their B-ring with o -diphenols have been reported as strong competitive inhibitors of tyrosinase 94,99,100,101,102 , which is associated with tyrosinase inhibition 99

Ageing Res Rev 59:101037

Thistle Extract (Silybum marianum) (seed) (80% silymarin) 210mg

doi: 10.1111/j.1600-0560.2008.01176.x 59 FerraraGAmanteaAArgenzianoGBroganelliPCesinaroAMDonatiPet al

Adults with a BMI of 25 or higher who havent achieved success with diet and exercise alone, and are in overall good health