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It has also been demonstrated to impair the uptake of essential amino acids by the transporter protein SLC38A2, thereby decreasing the cellular levels of these nutrients [175]

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Cho S, Lee YH, Park H et al (2001) Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1

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Similarly, at the order level (Fig

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy