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How do the potential benefits of GLP-1 agonists in reducing risks of heart and kidney disease compare with the risks of side effects like hypoglycemia or gallbladder disorders, and how should a clinician balance these considerations

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In contrast with SMAD2/3/4 , only the blockade of the MAPK/ERK cascade by U0126 and the PI3K/AKT signaling by AZD5363 attenuated the effect of TGF- on c-MET phosphorylation as well as HGF gene expression (Fig