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Conclusion: FOXO4-DRI promotes the nuclear export of phosphorylated P53 by inhibiting the binding of FOXO4 to P53 in endothelial cells, thereby facilitating the apoptosis of senescent endothelial cells and alleviating aging

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Nicotinamide N-methyl transferase (NNMT): an emerging therapeutic target

To address this, researchers are developing advanced delivery systems and chemical modifications

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