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Setmelanotide is administered once daily by subcutaneous injection

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At that concentration a 2 mg dose is 0.20 mL (20 units), 4 mg is 40 units, 8 mg is 80 units, and 12 mg is 120 units

Additional orthogonal controls include amino acid analysis (AAA) via acid hydrolysis then OPA derivatization, water content by Karl Fischer, residual salt content by conductometry or ion chromatography, and endotoxin analysis by LAL kinetic chromogenic

The shedding can be alarming, but remember: these are hairs that shifted into telogen months ago

Some patients prefer morning administration to allow any mild nausea to resolve during the day, while others may prefer evening injection if they experience fatigue or other symptoms following administration