Protection of pancreatic betacells by exendin4 may involve the reduction of endoplasmic reticulum stress
A total of 30 male BALB/c nude mice were randomly divided into four groups: a CT26 + 0.9%NaCl group (8 mice bearing CT26 tumors, treated with vehicle, as a control model of cancer cachexia), a 0.9%NaCl group (6 mice without tumors, treated with the vehicle, as normal controls), a CT26 + LC1 group (8 mice with CT26 tumors, treated with1 mg/kg bodyweight L-carnitine) and a CT26 + LC10 group (8 mice with CT26 tumors treated with10 mg/kg bodyweight L-carnitine)
The two main delivery methods are nasal spray and subcutaneous injection
Am J Physiol Endocrinol Metab 271(6):E990E995
Sulphydryl group derivatization with 2-vinylpyridine masks the reduced GSH so that only the GSH derived from the GR-mediated reduction of GSSG can react with DTNB
Taking Berberine led to a significant decrease in hemoglobin A1c from 9.5 to 7.5, fasting blood glucose from 10.6 to 6.9, and postprandial blood glucose from 19.8 to 11.1