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Due to the compounds plasma half-life of approximately 3.86.9 hours, twice-daily (BID) dosing may provide more sustained NNMT inhibition

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These effects tend to be dose-related, which is one reason microdosing appeals to people who struggled with higher-dose protocols

This narrative review is an attempt to elaborate and consolidate our current understanding of the molecular mechanisms of SARS-CoV-2 infection, the detrimental effect(s) of this infectious process on human metabolism, consequential symptomatic clinical manifestations, and damage to multiple organ systems